drugset / Trial / NCT01606488
Effects of Brain Beta-Amyloid on Postoperative Cognition
Phase 4
Active not recruiting
66 enrolled
University of California, San Francisco
Alzheimer's Drug Discovery Foundation · collabAvid Radiopharmaceuticals · collab
Non-randomizedParallel-groupOpen-labelDiagnostic
Summary
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.
Timeline
- Start
- 2012-05
- Primary completion
- 2026-06
- Completion
- 2026-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | florbetapir | Diagnostic / imaging agent | 370 mbq | Intravenous |
Indications
No indication recorded.