drugset / Trial / NCT01607918
Clarithromycin-based Triple Therapy for 14 Days Versus Sequential Therapy 10 Days in the First Line Therapy
RandomizedParallel-groupOpen-labelTreatment
Summary
The investigators aimed to compare the eradication rates of sequential therapy for 10 days versus triple therapy for 14 days
Timeline
- Start
- 2012-02
- Primary completion
- 2013-12
- Completion
- 2014-06
Outcome
Missed primary endpoint
paper CONCLUSIONS: S10 was not superior to T14 in areas with low clarithromycin resistance. PMID 26338825 ↗
Publications
- Results Romano M, Cuomo A, Gravina AG, Miranda A, Iovene MR, Tiso A, Sica M, Rocco A, Salerno R, Marmo R, Federico A, Nardone G. Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial. Gut. 2010 Nov;59(11):1465-70. doi: 10.1136/gut.2010.215350.
- Liou JM, Chen CC, Chang CY, Chen MJ, Chen CC, Fang YJ, Lee JY, Yang TH, Luo JC, Wu JY, Liou TC, Chang WH, Hsu YC, Tseng CH, Chang CC, Bair MJ, Liu TY, Hsieh CF, Tsao FY, Shun CT, Lin JT, Lee YC, Wu MS; Taiwan Gastrointestinal Disease and Helicobacter Consortium. Sequential therapy for 10 days versus triple therapy for 14 days in the eradication of Helicobacter pylori in the community and hospital populations: a randomised trial. Gut. 2016 Nov;65(11):1784-1792. doi: 10.1136/gutjnl-2015-310142. Epub 2015 Sep 3.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | 1 g | — |
| Subject | Clarithromycin | Small molecule | 500 mg | — |
| Subject | Lansoprazole | Other / unclassified | 30 mg | — |
| Subject | Metronidazole | Small molecule | 500 mg | — |
Indications
No indication recorded.