Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque

Phase 1/2 Terminated 20 enrolled University of Lausanne Hospitals Swiss Heart Foundation · collab

NaSingle-groupOpen-labelDiagnostic

Summary

The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology. Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.

Timeline

Start: 2012-04
Primary completion: 2026-07
Completion: 2026-07

Outcome

Outcome not reported

Stopped (Enrollment): “studdy stopped because of patient recruitment issues”

Publications

Gnesin S, Mitsakis P, Cicone F, Deshayes E, Dunet V, Gallino AF, Kosinski M, Baechler S, Buchegger F, Viertl D, Prior JO. First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK. EJNMMI Res. 2017 Dec;7(1):43. doi: 10.1186/s13550-017-0288-x. Epub 2017 May 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	68Ga-NODAGA-RGD	Diagnostic / imaging agent	200 mbq	Intravenous