Comparison of Body Weight Change During Contraception With Belara and Yasmin

Summary

The purpose of this study is to evaluate different side effect in contraceptive use of two oral combined contraceptive pills (OCP)in combination of 30 mcg ethinylestradiol/2 mg chlormadinone acetate (Belara®) and 30 mcg ethinylestradiol/3 mg drospirenone (Yasmin®), especially body weight change.

Timeline

Start

2012-06

Primary completion

2016-01

Completion

2016-02

Outcome

Met primary endpoint

paper A significant difference was observed in mean body weight change between the EE/CMA and EE/DRSP groups PMID 31756117 ↗

paper baseline to sixth cycle (1.00 ± 1.84 kg vs -0.20 ± 2.23 kg; p = .013). PMID 31756117 ↗

Publications

• Wongwananuruk T, Panichyawat N, Panchalee T, Jirakittidul P, Angsuwathana S, Sirimai K, Thamkhantho M, Chiravacharadej G. Comparison of change in body weight between contraception containing 30-mug ethinylestradiol/2-mg chlormadinone acetate or 30-mug ethinylestradiol/3-mg drospirenone: a randomised controlled trial. Eur J Contracept Reprod Health Care. 2020 Feb;25(1):43-48. doi: 10.1080/13625187.2019.1688290. Epub 2019 Nov 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	chlormadinone acetate	Small molecule	2 mg	Oral
Subject	drospirenone	Unknown	3 mg	Oral
Subject	ethinyl estradiol	Small molecule	30 ug	Oral

Indications

No indication recorded.