Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy

Phase 4 Completed 328 enrolled Heinrich-Heine University, Duesseldorf

RandomizedParallel-groupQuadruple-blindTreatment

Summary

A study to examine whether an antipsychotic combination treatment of olanzapine and amisulpride is more effective than olanzapine and amisulpride alone.

Timeline

Start: 2012-06
Primary completion: 2019-04
Completion: 2019-04

Publications

Schmidt-Kraepelin C, Feyerabend S, Engelke C, Riesbeck M, Meisenzahl-Lechner E, Verde PE, Correll CU, Kluge M, Makiol C, Neff A, Lange C, Englisch S, Zink M, Langguth B, Poeppl TB, Reske D, Gouzoulis-Mayfrank E, Grunder G, Hasan A, Brockhaus-Dumke A, Jager M, Baumgartner J, Leucht S, Cordes J; COMBINE Study Group. Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial. Lancet Psychiatry. 2022 Apr;9(4):291-306. doi: 10.1016/S2215-0366(22)00032-3. Epub 2022 Mar 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amisulpride	Small molecule	200 mg	Oral
Comparator	Amisulpride	Small molecule	800 mg	Oral
Comparator	Olanzapine	Small molecule	5 mg	Oral
Comparator	Olanzapine	Small molecule	20 mg	Oral

Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy

Summary

Timeline

Publications

Drugs

Indications