drugset / Trial / NCT01615796
Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Repeat IV Doses
RandomizedSingle-groupSingle-blindOther
Summary
GSK2140944 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK2140944 has demonstrated in vitro and in vivo activity against Gram positive pathogens including methicillin resistant Staphylococcus aureus (MRSA) and Gram-negative pathogens associated with respiratory tract, skin and soft tissue infections including isolates resistant to existing classes of antimicrobials.
Timeline
- Start
- 2012-06-04
- Primary completion
- 2014-02-21
- Completion
- 2014-02-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gepotidacin | Small molecule | 200 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 400 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 600 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 750 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 1000 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 1200 mg | Intravenous |
| Subject | Gepotidacin | Small molecule | 1800 mg | Intravenous |