drugset / Trial / NCT01615796

Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Repeat IV Doses

NCT01615796

Phase 1 Completed 86 enrolled GlaxoSmithKline
RandomizedSingle-groupSingle-blindOther

Summary

GSK2140944 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK2140944 has demonstrated in vitro and in vivo activity against Gram positive pathogens including methicillin resistant Staphylococcus aureus (MRSA) and Gram-negative pathogens associated with respiratory tract, skin and soft tissue infections including isolates resistant to existing classes of antimicrobials.

Timeline

Start
2012-06-04
Primary completion
2014-02-21
Completion
2014-02-21

Drugs

EvaluationDrugModalityDoseRoute
Subject Gepotidacin Small molecule 200 mg Intravenous
Subject Gepotidacin Small molecule 400 mg Intravenous
Subject Gepotidacin Small molecule 600 mg Intravenous
Subject Gepotidacin Small molecule 750 mg Intravenous
Subject Gepotidacin Small molecule 1000 mg Intravenous
Subject Gepotidacin Small molecule 1200 mg Intravenous
Subject Gepotidacin Small molecule 1800 mg Intravenous