Multicentre Canadian Study to Measure the Safety and Efficacy of Radiosynoviorthesis

Summary

Radiation synovectomy by intra-articular injection of beta-emitting radionuclides is considered a reliable and easy-to-perform therapy without harmful side-effects for the treatment of inflammatory joint disease in many countries. The goal of this study is to demonstrate Yttrium-90 citrate colloid or Rhenium-186 sulfide synovectomy are appropriate therapeutic interventions in patients with persistent active synovitis of a joint (characterized by pain, tenderness, and effusion) which is resistant to systemic therapy and intra-articular corticosteroid injections. The primary objective will be to assess the safety of an intra-articular administration of Yttrium-90 citrate colloid or Rhenium-186 sulfide. The secondary objective will be to assess the efficacy on synovitis.

Timeline

Start

2012-05-31

Primary completion

2017-12-31

Completion

2018-12-31

Publications

• Desaulniers M, Paquette M, Dubreuil S, Senta H, Lavallee E, Thorne JC, Turcotte E. Safety and Efficacy of Radiosynoviorthesis: A Prospective Canadian Multicenter Study. J Nucl Med. 2024 Jul 1;65(7):1095-1100. doi: 10.2967/jnumed.123.267297.

Drugs

Indications