drugset / Trial / NCT01617746
Examination of the Bronchoprotective Effect of Endothelin Receptor Blockade in Asthma
RandomizedCrossoverQuadruple-blindTreatment
Summary
The purpose of this study will be to determine if blockade of endothelin 1 signalling via endothelin receptor A using ambrisentan or dual blockade (A\&B) via bosentan can provide protection against methacholine induced bronchoconstriction in asthma.
Timeline
- Start
- 2012-11
- Primary completion
- 2014-05
- Completion
- 2015-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ambrisentan | Small molecule | 5 mg | — |
| Subject | Bosentan | Other / unclassified | 62.5 mg | — |