drugset / Trial / NCT01624428

Varenicline on Reward Responses and Cognition in Adolescent Smokers

NCT01624428

Phase 1 Completed 16 enrolled Yale University
RandomizedParallel-groupTriple-blindBasic science

Summary

This is a pilot project using functional magnetic resonance imaging (fMRI) to examine the influence of varenicline on reward processing, cognitive control, and regulation of craving in adolescent smokers. We hypothesize that adolescent smokers receiving varenicline, when compared with those receiving placebo, will have differential brain responses to anticipation of rewards, during exposure to the Stroop task, and in response to tobacco cues.

Timeline

Start
2012-06
Primary completion
2013-11
Completion
2013-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Varenicline Small molecule 1 mg

Indications