D-Cycloserine as an Adjunct to Internet-CBT for OCD

Phase 4 Completed 128 enrolled Christian Rück Königska · collab Region Stockholm · collab The Swedish Research Council · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to examine if D-Cycloserine is an effective adjunct to internet-based cognitive behaviour therapy for patients with obsessive-compulsive disorder.

Timeline

Start: 2012-08
Primary completion: 2016-06
Completion: 2016-06

Outcome

Missed primary endpoint

paper In the primary intention-to-treat analyses, DCS did not augment the effects of CBT compared with placebo PMID 25970252 ↗

Publications

Results Andersson E, Hedman E, Enander J, Radu Djurfeldt D, Ljotsson B, Cervenka S, Isung J, Svanborg C, Mataix-Cols D, Kaldo V, Andersson G, Lindefors N, Ruck C. D-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Jul;72(7):659-67. doi: 10.1001/jamapsychiatry.2015.0546.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cycloserine	Small molecule	50 mg	—