drugset / Trial / NCT01659242
Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study
RandomizedParallel-groupSingle-blindTreatment
Summary
In rheumatoid arthritis patients with active disease despite optimal treatment with methotrexate, the main objective of this pilot study is to use advance imaging tools such as magnetic resonance imaging and ultrasound to evaluate which treatment option is more efficacious: initiating methotrexate/sulfasalazine combination therapy, or switching to leflunomide monotherapy
Timeline
- Start
- 2012-07
- Primary completion
- 2012-12
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Leflunomide | Small molecule | 20 mg | Oral |
| Comparator | Methotrexate | Small molecule | — | — |
| Comparator | Sulfasalazine | Small molecule | 2 g | Oral |