drugset / Trial / NCT01659242

Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study

NCT01659242

Phase 4 Terminated 1 enrolled Singapore General Hospital
RandomizedParallel-groupSingle-blindTreatment

Summary

In rheumatoid arthritis patients with active disease despite optimal treatment with methotrexate, the main objective of this pilot study is to use advance imaging tools such as magnetic resonance imaging and ultrasound to evaluate which treatment option is more efficacious: initiating methotrexate/sulfasalazine combination therapy, or switching to leflunomide monotherapy

Timeline

Start
2012-07
Primary completion
2012-12
Completion

Drugs

EvaluationDrugModalityDoseRoute
Comparator Leflunomide Small molecule 20 mg Oral
Comparator Methotrexate Small molecule
Comparator Sulfasalazine Small molecule 2 g Oral

Indications