drugset / Trial / NCT01675986

Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score

NCT01675986

Phase 2 Completed 306 enrolled Poitiers University Hospital

Summary

The insertion of long-lasting intravenous device is done under local anesthesia. Currently, in the investigators hospital, no premedication is given to the patients. However, this procedure occurs in a particular emotional context related to the diagnosis of cancer or malign hemopathies. Therefore, administration of a sedative or anxiolytic drugs before the start of the procedure can be questionable. Hydroxyzine is the reference molecule for premedication because of its anxiolytic and anti-histaminic properties A new agent, pregabalin, shares also the same properties The main objective of this study was to compare the efficacy of pregabalin and hydroxyzine on the anxiety score as a premedication during the insertion of long-lasting intravenous device under local anesthesia.

Timeline

Start
Primary completion
2014-11
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject Hydroxyzine Small molecule 75 mg
Subject Pregabalin Small molecule 150 mg

Indications