drugset
drugset / Trial / NCT01676246

Pharmacokinetics, Metabolism and Analgesic Effects of Flupirtine

NCT01676246 ↗

Phase 1 Completed 36 enrolled University Medicine Greifswald AWD.pharma GmbH & Co. KG · collab
RandomizedCrossoverOpen-labelBasic science

Summary

Flupirtine is metabolized in-vitro via carbamate cleavage and N acetylation to glucuronides and mercapturic acid derivatives. The formation of reactive, toxic intermediate products may be influenced by genetic polymorphisms of the involved conjugative metabolic pathways. So the purpose of this study is to measure pharmacokinetics, metabolism and analgesic effects of flupirtine in dependence on the function of NAT2, UGT1A1 and GSTP1.

Timeline

Start
2008-05
Primary completion
2009-05
Completion
2009-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Flupirtine Small molecule 100 mg Intravenous
Comparator Flupirtine Small molecule 400 mg Intravenous

Indications

No indication recorded.