Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus

Phase 4 Completed 64 enrolled Medical University of Warsaw

RandomizedCrossoverQuadruple-blindTreatment

Summary

The aim of this study is to determine whether insulin glulisine is more effective in postprandial glycemic control than insulin aspart after the H-GI meal in children with type 1 diabetes (T1DM) treated with insulin pump (CSII).

Timeline

Start: 2011-09
Primary completion: 2012-09
Completion: 2012-09

Outcome

Missed primary endpoint

paper THERE WERE NO SIGNIFICANT DIFFERENCES BETWEEN THE GROUPS WITH REGARD TO PPG IN THE DETERMINED TIME INTERVALS PMID 24412929 ↗

Publications

Results Dzygalo K, Szypowska A. Impact of insulins glulisine and aspart on postprandial glycemia after a high-glycemic index meal in children with type 1 diabetes. Eur J Endocrinol. 2014 Mar 8;170(4):539-45. doi: 10.1530/EJE-13-0696. Print 2014 Apr.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Insulin glulisine	Protein / enzyme biologic	—	—
Subject	insulin aspart	Protein / enzyme biologic	—	—