Evaluation Of The Potential Effect That The Administration Of Food Or Antacid Medication May Have In The Oral Absorption Of Dacomitinib (PF-00299804)

Phase 1 Completed 24 enrolled Pfizer

RandomizedCrossoverOpen-labelBasic science

Summary

Evaluation of the potential effect that the administration of food or antacid medication may have in the oral absorption of dacomitinib relative to the administration of dacomitinib in absence of food or antacid medication

Timeline

Start: 2012-10
Primary completion: 2013-01
Completion: 2013-01

Publications

Ruiz-Garcia A, Masters JC, Mendes da Costa L, LaBadie RR, Liang Y, Ni G, Ellery CA, Boutros T, Goldberg Z, Bello CL. Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers. J Clin Pharmacol. 2016 Feb;56(2):223-30. doi: 10.1002/jcph.588. Epub 2015 Oct 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	DACOMITINIB ANHYDROUS	Small molecule	45 mg	Oral
Subject	Rabeprazole	Small molecule	40 mg	—

Indications

No indication recorded.