Riluzole Augmentation Pilot in Depression (RAPID) Trial
Summary
The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression. This research study will compare riluzole + sertraline to placebo + sertraline. The investigators hypothesize that adding riluzole will lead to a better antidepressant response, in less time, then sertraline alone.
Timeline
- Start
- 2013-01
- Primary completion
- 2018-06
- Completion
- 2018-06
Outcome
Missed primary endpoint
Stopped (Enrollment): “PI departure, slow recruitment”
registry analysis (superiority test); Sertraline + Riluzole vs Sertraline + Placebo; p = 0.06; ANOVA NCT01703039 ↗
registry analysis (superiority test); Sertraline + Riluzole vs Sertraline + Placebo; p = 0.31; Chi-squared NCT01703039 ↗
registry analysis (superiority test); Sertraline + Riluzole vs Sertraline + Placebo; p = 0.34; Chi-squared NCT01703039 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Riluzole | Small molecule | 50 mg | Oral |
| Background | Sertraline | Small molecule | 100 mg | Oral |