Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial

Summary

The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.

Timeline

Start

2012-11

Primary completion

2017-05

Completion

2017-06-30

Outcome

Missed primary endpoint

paper However, the efficacy of propranolol was not greater than that of placebo 1 week post treatment. PMID 33612830 ↗

Publications

• Results Very E, Leroy A, Richaud L, Vaiva G, Jardri R, Roullet P, Taib S, Bourcier A, Loubinoux I, Birmes P. Hippocampal connectivity changes after traumatic memory reactivation with propranolol for posttraumatic stress disorder: a randomized fMRI study. Eur J Psychotraumatol. 2025 Dec;16(1):2466886. doi: 10.1080/20008066.2025.2466886. Epub 2025 Apr 22.
• Results Roullet P, Taib S, Thalamas C, Vaiva G, El Hage W, Yrondi A, Birmes P. Efficacy of traumatic memory reactivation with or without propranolol in PTSD with high dissociative experiences. Eur J Psychotraumatol. 2022 Dec;13(2):2151098. doi: 10.1080/20008066.2022.2151098. Epub 2022 Dec 1.
• Results Roullet P, Vaiva G, Very E, Bourcier A, Yrondi A, Dupuch L, Lamy P, Thalamas C, Jasse L, El Hage W, Birmes P. Traumatic memory reactivation with or without propranolol for PTSD and comorbid MD symptoms: a randomised clinical trial. Neuropsychopharmacology. 2021 Aug;46(9):1643-1649. doi: 10.1038/s41386-021-00984-w. Epub 2021 Feb 21.
• Results Leroy A, Very E, Birmes P, Yger P, Szaffarczyk S, Lopes R, Outteryck O, Faure C, Duhem S, Grandgenevre P, Warembourg F, Vaiva G, Jardri R. Intrusive experiences in posttraumatic stress disorder: Treatment response induces changes in the directed functional connectivity of the anterior insula. Neuroimage Clin. 2022;34:102964. doi: 10.1016/j.nicl.2022.102964. Epub 2022 Feb 10.

Drugs

Indications