Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma

Phase 3 Completed 50 enrolled Seoul National University Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The investigators want to know whether the intravenous ascorbic acid would reduce the blood loss during laparoscopic myoma surgery. The investigators randomized patients into intravenous ascorbic acid group and placebo group and examined the blood loss in both groups.

Timeline

Start: 2012-12
Primary completion: 2017-10
Completion: 2017-10

Outcome

Missed primary endpoint

paper as was the intraoperative blood loss (193±204mL vs. 159±193mL, P=0.52). PMID 26946313 ↗

paper Intravenous ascorbic acid infusion did not reduce intraoperative blood loss in women undergoing laparoscopic myomectomy. PMID 26946313 ↗

Publications

Lee B, Kim K, Cho HY, Yang EJ, Suh DH, No JH, Lee JR, Hwang JW, Do SH, Kim YB. Effect of intravenous ascorbic acid infusion on blood loss during laparoscopic myomectomy: a randomized, double-blind, placebo-controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:187-91. doi: 10.1016/j.ejogrb.2016.02.014. Epub 2016 Feb 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin C	Other / unclassified	2 g	Intravenous