drugset / Trial / NCT01715896

A Study of Mavrilimumab Versus Anti Tumor Necrosis Factor in Subjects With Rheumatoid Arthritis

NCT01715896

Phase 2 Completed 215 enrolled MedImmune LLC
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The primary objectives of this study is to explore the efficacy of mavrilimumab compared with golimumab in the treatment of adult subjects 18-80 years of age with moderate-to-severe active rheumatoid arthritis (RA) who have an inadequate response to one or more conventional disease-modifying anti-rheumatic drugs (DMARDs) and/or one or two anti-tumor necrosis factor (TNF) agents (excluding golimumab) for efficacy or safety reasons.

Timeline

Start
2013-03
Primary completion
2014-11
Completion
2015-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Golimumab Monoclonal antibody 50 mg Subcutaneous
Subject Mavrilimumab Monoclonal antibody 100 mg Subcutaneous

Indications