Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid Arthritis

Summary

The purpose of this study is to determine whether aminopterin is effective in the treatment of rheumatoid arthritis (RA).

Timeline

Start

2013-02

Primary completion

2014-09

Completion

2015-02

Publications

• Results Menter A, Thrash B, Cherian C, Matherly LH, Wang L, Gangjee A, Morgan JR, Maeda DY, Schuler AD, Kahn SJ, Zebala JA. Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter. J Pharmacol Exp Ther. 2012 Sep;342(3):696-708. doi: 10.1124/jpet.112.195479. Epub 2012 May 31.

Drugs

Indications