A Study of Effect of Deodorant and Axillary Hair on Testosterone Absorption in Healthy Participants

Phase 1 Completed 30 enrolled Eli Lilly and Company

RandomizedCrossoverOpen-labelBasic science

Summary

This study will evaluate the effect of deodorant and antiperspirant use and the presence of underarm hair on the absorption of testosterone. Each participant in this study will receive 6 single doses of 30 milligrams (mg) testosterone applied as a solution to each underarm. There is a minimum one day washout period between each dose. This study will last approximately 24 days not including screening. Screening is required within 30 days prior to the start of the study.

Timeline

Start: 2012-11
Primary completion: 2013-01
Completion: 2013-01

Publications

Small DS, Ni X, Polzer P, Vart R, Satonin DK, Mitchell MI. Effect of deodorant and antiperspirant use and presence or absence of axillary hair on absorption of testosterone 2% solution applied to men's axillae. J Sex Med. 2014 Nov;11(11):2809-17. doi: 10.1111/jsm.12658. Epub 2014 Aug 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Testosterone	Small molecule	30 mg	Topical

Indications

No indication recorded.