Stereotactic Body Radiation With Nelfinavir for Oligometastases

Phase 2 Completed 38 enrolled Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NaSingle-groupOpen-labelTreatment

Summary

Patients with metastatic lesions of the lung, liver, or bone will be candidates for treatment. Within three weeks of the initial treatment planning, a 15 Gy dose (per lesion site) of SBRT will be administered. Prior to SBRT, patients will initiate Nelfinavir oral therapy twice daily for 7 days. Once SBRT is completed, the patient will repeat the same Nelfinavir therapy for an additional 7 days for a total of 14 days of treatment.

Timeline

Start: 2014-01-08
Primary completion: 2020-03
Completion: 2020-12

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nelfinavir	Other / unclassified	1250 mg	Oral

Indications

No indication recorded.