Factors Affecting Methamphetamine and Opiates Drug Testing

Summary

Background: \- Some legal over-the-counter drugs (such as Vicks VapoInhaler ) and some foods (such as poppy seeds) may cause a positive screening drug test. This might look like someone used illegal drugs (such as methamphetamines or opiates) when they did not. Researchers are studying how the body handles chemicals that may test like illegal drugs and for how long they may be detected in the body. Blood, saliva, and urine samples will be collected. This study may help improve the effectiveness and accuracy of drug tests. Objectives: \- To see how the body handles chemicals that may produce positive screening tests and how additional testing can eliminate positive drug tests from over-the-counter drugs and food. Eligibility: \- Healthy volunteers between 18 and 65 years of age. Design: * Participants are screened with a physical exam, medical history, laboratory tests, and ECG. * This study involves an overnight stay on a secure research unit and 2 days of tests. * On the first day, participants will take Vicks VapoInhaler (two inhalations in each nostril) every 2 hours from 9 a.m. to 7 p.m. They will also take a drink containing poppy seeds twice (at about 9 a.m. and 5 p.m.). * On the morning of the second day, participants will take the Vicks VapoInhaler just once. They will be discharged around 5 p.m. * On both days, participants will provide blood and saliva samples several times throughout the day. All of their urine will be collected during the 2 study days....

Timeline

Start

2012-07-19

Primary completion

2014-01-31

Completion

2014-01-31

Publications

• Background Crivellaro M, Bonadonna P, Dama A, Senna GE, Mezzelani P, Mistrello G, Passalacqua G. Severe systemic reactions caused by poppy seed. J Investig Allergol Clin Immunol. 1999 Jan-Feb;9(1):58-9.
• Background Dufka F, Galloway G, Baggott M, Mendelson J. The effects of inhaled L-methamphetamine on athletic performance while riding a stationary bike: a randomised placebo-controlled trial. Br J Sports Med. 2009 Oct;43(11):832-5. doi: 10.1136/bjsm.2008.048348. Epub 2008 Nov 3.
• Background Fritschi G, Prescott WR Jr. Morphine levels in urine subsequent to poppy seed consumption. Forensic Sci Int. 1985 Feb;27(2):111-7. doi: 10.1016/0379-0738(85)90173-2.

Drugs

Indications

No indication recorded.