drugset / Trial / NCT01742338

Dose of Corticosteroids in COPD

NCT01742338 ↗

Phase 4 Terminated 89 enrolled Rutgers, The State University of New Jersey
RandomizedParallel-groupQuadruple-blindTreatment

Summary

COPD (chronic obstructive pulmonary disease) is a long-lasting lung disease usually caused by long-term smoking. COPD can get worse, making people sick enough to need hospitalization. Corticosteroids are very effective and are almost always used, but nobody knows the right dose. High doses may work better but could cause more side effects than low doses. Typical treatment lengths last at least one week. This study will be comparing two common regimens: either 40mg of corticosteroids daily (low dose), or 80mg of corticosteroids daily (high dose). It is unknown which regimen works better..

Timeline

Start
2012-05-03
Primary completion
2020-03-15
Completion
2020-03-15

Outcome

Outcome not reported

Stopped (Enrollment): “Lack of research staff to recruit participants”

Drugs

EvaluationDrugModalityDoseRoute
Comparator Methylprednisolone Other / unclassified 10 mg Intravenous
Comparator Methylprednisolone Other / unclassified 40 mg Intravenous
Comparator Prednisone Other / unclassified 40 mg Oral
Comparator Prednisone Other / unclassified 80 mg Oral