Study of Telbivudine and Lamivudine to Prevent Vertical Transmission of Hepatitis B

Phase 4 Completed 700 enrolled Beijing YouAn Hospital New Discovery LLC · collab

Non-randomizedParallel-groupOpen-labelPrevention

Summary

The purpose of this study is to evaluate the efficacy and safety of telbivudine and lamivudine use during late pregnancy for the prevention of HBV perinatal transmission in highly viraemic mothers.

Timeline

Start: 2009-01
Primary completion: 2013-07
Completion: 2013-07

Publications

Zhang H, Pan CQ, Pang Q, Tian R, Yan M, Liu X. Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice. Hepatology. 2014 Aug;60(2):468-76. doi: 10.1002/hep.27034. Epub 2014 Jan 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lamivudine	Other / unclassified	100 mg	—
Subject	Telbivudine	Small molecule	600 mg	—

Study of Telbivudine and Lamivudine to Prevent Vertical Transmission of Hepatitis B

Summary

Timeline

Publications

Drugs

Indications