drugset / Trial / NCT01743300
The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients
Non-randomizedSingle-groupOpen-label
Summary
In this prospective pharmacokinetic we investigate the following topics: * The influence of grapefruit juice and orange juice on the steady-state pharmacokinetics of sunitinib in cancer patients * The influence of sunitinib on the pharmacokinetics of midazolam in cancer patients * The relationship between Cytochrome-P450-3A4 (CYP3A4) phenotype, as assessed using the midazolam clearance test, and the steady-state pharmacokinetics of sunitinib in cancer patients * The effect of grapefruit juice and orange juice on CYP3A4 metabolism
Timeline
- Start
- 2007-07
- Primary completion
- 2010-12
- Completion
- 2010-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Midazolam | Small molecule | 7.5 mg | Oral |
| Comparator | Sunitinib | Small molecule | 50 mg | Oral |
Indications
No indication recorded.