Comparison Between 2L Coolprep® and Combination of 1L Coolprep® and Bisacodyl as Bowel Preparation

Phase 3 Completed 196 enrolled Seoul National University Hospital

RandomizedParallel-groupSingle-blindDiagnostic

Summary

comparison of the use of Colyte® (ascorbic acid mixed polyethylene glycol solution) in two-liter versus one-liter volume and pretreatment with bisacodyl for colonoscopy preparation.

Timeline

Start: 2013-01-30
Primary completion: 2013-08-31
Completion: 2014-01-31

Outcome

Met primary endpoint

paper CONCLUSIONS: Bowel preparation with Bis and a 1-L PEG/Asc solution is as effective, well-tolerated, and safe as a 2-L PEG/Asc solution. PMID 27588943 ↗

Publications

Kwon JE, Lee JW, Im JP, Kim JW, Kim SH, Koh SJ, Kim BG, Lee KL, Kim SG, Kim JS, Jung HC. Comparable Efficacy of a 1-L PEG and Ascorbic Acid Solution Administered with Bisacodyl versus a 2-L PEG and Ascorbic Acid Solution for Colonoscopy Preparation: A Prospective, Randomized and Investigator-Blinded Trial. PLoS One. 2016 Sep 2;11(9):e0162051. doi: 10.1371/journal.pone.0162051. eCollection 2016.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bisacodyl	Small molecule	20 mg	Oral
Comparator	Coolprep	Unknown	1000 ml	—
Comparator	Coolprep	Unknown	2000 ml	—

Indications

No indication recorded.