Shensongyangxin Capsule in the Treatment of Sinus Bradycardia With Premature Ventricular Contractions

Phase 4 Unknown 330 enrolled kejiang Cao Chinese Academy of Medical Sciences, Fuwai Hospital · collab Third Military Medical University · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to assess the effects of Chinese medicine Shansong Yangxin capsule for sinus bradycardia complicated with ventricular premature beats.

Timeline

Start: 2012-08
Primary completion: 2013-09
Completion: 2013-12

Outcome

Met primary endpoint

paper SSYX reduced PVCs burden by 68.2% (p < 0.001) PMID 30949218 ↗

paper and increased MHR by 10.9% (p < 0.001) compared to 32.2% and 4.7%, respectively, in the placebo group. PMID 30949218 ↗

Publications

Zhang F, Zou J, Yu H, Li X, Kojodjojo P, Cai X, Zhang S, Huang C, Hong K, Yu B, Li G, Luo S, Zhou S, Zheng Y, Fan J, Cao X, Tao G, Sheng G, Bai Z, Jiang S, Liu X, Gu W, Chen F, Cao K. Acute Efficacy of a Traditional Chinese Medicine for Treatment of Frequent Premature Ventricular Contractions in Patients with Concomitant Sinus Bradycardia: Results from a Double-Blind, Placebo-Controlled, Multicentre, Randomized Clinical Trial. Evid Based Complement Alternat Med. 2019 Mar 4;2019:3917282. doi: 10.1155/2019/3917282. eCollection 2019.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Shensong Yangxin	Traditional medicine (herbal / TCM)	4 unknown	Oral