Dutasteride Treatment for the Reduction of Heavy Drinking in Men

Phase 4 Completed 189 enrolled UConn Health National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study will examine the safety and potential benefit of the medication dutasteride to help men reduce or stop drinking alcohol.

Timeline

Start: 2013-01
Primary completion: 2018-02-28
Completion: 2018-02-28

Outcome

Mixed primary results

registry analysis (other test); Dutasteride vs Sugar Pill; p = 0.002; Mixed Models Analysis NCT01758523 ↗

paper CONCLUSION: Dutasteride 1 mg daily was efficacious in reducing the number of heavy drinking days and drinks per week in treatment-seeking men. PMID 38684046 ↗

registry analysis (other test); Dutasteride vs Sugar Pill; p = 0.057; Odds Ratio (OR) 2.49 (95% CI 0.96 to 6.45); Chi-squared NCT01758523 ↗

Publications

Covault J, Tennen H, Feinn R. Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men. J Clin Psychopharmacol. 2024 May-Jun 01;44(3):223-231. doi: 10.1097/JCP.0000000000001849.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dutasteride	Small molecule	1 mg	Oral