Effect of Erythropoietin on the Incidence of Acute Kidney Injury Following Complex Valvular Heart Surgery

Phase 2 Completed 98 enrolled Yonsei University

RandomizedParallel-groupTriple-blindPrevention

Summary

Acute kidney injury (AKI) frequently occurs after cardiac surgery using cardiopulmonary bypass (CPB). Recombinant human erythropoietin (rHuEPO) is known to provide organ protection against ischemia-reperfusion injury through its anti-inflammatory properties. The aim of the present study was to investigate the effect of a single preoperative bolus of EPO on the incidence of AKI following complex valvular heart surgery in a randomized, controlled and double-blind trial.

Timeline

Start: 2011-07
Primary completion: 2012-09
Completion: 2012-10

Outcome

Missed primary endpoint

paper Incidence of postoperative AKI (32.7% versus 34.7%, P = 0.831) PMID 24156702 ↗

Publications

Kim JH, Shim JK, Song JW, Song Y, Kim HB, Kwak YL. Effect of erythropoietin on the incidence of acute kidney injury following complex valvular heart surgery: a double blind, randomized clinical trial of efficacy and safety. Crit Care. 2013 Oct 24;17(5):R254. doi: 10.1186/cc13081.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	recombinant human erythropoietin	Protein / enzyme biologic	300 iu/kg	Intravenous