NSAID Effects on Clinical and Imaging Breast Biomarkers

Phase 2 Completed 114 enrolled Stony Brook University

Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study has two purposes. One is to determine if daily sulindac decreases breast density; a risk factor for breast cancer development. The second is to determine whether sulindac reduces pain and stiffness associated with regular use of aromatase inhibitors given for the treatment of breast cancer.

Timeline

Start: 2012-12
Primary completion: 2019-02-07
Completion: 2019-03-11

Publications

Martinez JA, Wertheim BC, Roe DJ, Chalasani P, Cohen J, Baer L, Chow HS, Stopeck AT, Thompson PA. Sulindac Improves Stiffness and Quality of Life in Women Taking Aromatase Inhibitors for Breast Cancer. Breast Cancer Res Treat. 2022 Feb;192(1):113-122. doi: 10.1007/s10549-021-06485-0. Epub 2022 Jan 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sulindac	Small molecule	150 mg	—

NSAID Effects on Clinical and Imaging Breast Biomarkers

Summary

Timeline

Publications

Drugs

Indications