The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction

Phase 4 Completed 50 enrolled Brian Walters

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this research study is to investigate whether or not platelet rich plasma (PRP) may help to improve tendon healing and decrease post operative pain in patients undergoing anterior cruciate ligament (ACL) reconstructive surgery using their own patellar tendons as autografts.

Timeline

Start: 2012-12
Primary completion: 2017-08
Completion: 2017-08

Outcome

Missed primary endpoint

registry analysis (superiority test); PRP Treatment vs Sham; p = 0.55; Mean Difference (Final Values) 0.48 (95% CI -1.99 to 1.03); t-test, 2 sided NCT01765712 ↗

Publications

Walters BL, Porter DA, Hobart SJ, Bedford BB, Hogan DE, McHugh MM, Klein DA, Harousseau K, Nicholas SJ. Effect of Intraoperative Platelet-Rich Plasma Treatment on Postoperative Donor Site Knee Pain in Patellar Tendon Autograft Anterior Cruciate Ligament Reconstruction: A Double-Blind Randomized Controlled Trial. Am J Sports Med. 2018 Jul;46(8):1827-1835. doi: 10.1177/0363546518769295. Epub 2018 May 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Platelet Rich Plasma	Other / unclassified	—	Other

Indications

No indication recorded.