Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Motor Fluctuations

Summary

The primary objective of the study is to assess the efficacy, carbidopa dose response and safety of ODM-101, a new combination of levodopa, carbidopa and entacapone in the treatment of Parkinson's disease (PD) patients with end-of-dose motor fluctuations.

Timeline

Start

2011-05

Primary completion

2012-08

Completion

2012-09

Publications

• Trenkwalder C, Kuoppamaki M, Vahteristo M, Muller T, Ellmen J. Increased dose of carbidopa with levodopa and entacapone improves "off" time in a randomized trial. Neurology. 2019 Mar 26;92(13):e1487-e1496. doi: 10.1212/WNL.0000000000007173. Epub 2019 Mar 1.

Drugs

Indications