drugset / Trial / NCT01769079

Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina

NCT01769079 ↗

Phase 4 Completed 95 enrolled Hospital de Clinicas de Porto Alegre
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Chronic treatment of stable angina with nitrates long and short action is extremely frequent. In clinical practice the most commonly observed is a combination of anti-anginal agents, usually including nitrates fixed in an attempt to improve the quality of life of patients, which is not always met with success. Numerous questions and problems are seen with chronic use of oral nitrates. From a practical standpoint, some advocate the withdrawal of medication in stable patients, while many physicians still hesitate to withdraw the medication by the lack of definitive information about its consequences. In this sense there is a rationale for the attempted removal of nitrate fixed these patients, although evidence to support this action have not been adequately evaluated.

Timeline

Start
2009-09
Primary completion
2013-12
Completion
2013-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Isosorbide Unknown — Oral

Indications