Investigation of Potential Drug-drug Interaction of Volasertib With Itraconazole in Patients With Various Tumours

Summary

The primary objective of the present study is to investigate the influence of co-administration of itraconazole and volasertib on the pharmacokinetic profile of volasertib without co-administration of itraconazole. Secondary objectives are to investigate safety, tolerability and preliminary therapeutic effects following intravenous administration of volasertib.

Timeline

Start

2013-02-04

Primary completion

2014-05-30

Completion

2021-04-22

Publications

• Lang I, Liu D, Fritsch H, Taube T, Chizhikov E, Liptai B. Potential Drug-Drug Interactions with Combination Volasertib + Itraconazole: A Phase I, Fixed-sequence Study in Patients with Solid Tumors. Clin Ther. 2020 Nov;42(11):2214-2224. doi: 10.1016/j.clinthera.2020.09.015. Epub 2020 Nov 1.

Drugs

Indications