drugset / Trial / NCT01814410
Interactive Effects of IV Ethanol and IV Nicotine
Phase 0
Completed
5 enrolled
Yale University
South Central VA Mental Illness Research, Education & Clinical Center · collab
RandomizedCrossoverSingle-blindBasic science
Summary
There are mixed reports on nicotine's effects on ethanol-induced impairment in cognitive performance and behavior in humans. The main objective of this study is to characterize the interactive effects of acute intravenous (IV) ethanol and nicotine administration on cognition and behavior in healthy smokers. The general hypothesis is that nicotine will attenuate the negative effects of ethanol on cognition and subjective stimulant/sedative effects of ethanol.
Timeline
- Start
- 2013-02-22
- Primary completion
- 2014-06
- Completion
- 2014-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Alcohol | Other / unclassified | 40 % | Intravenous |
| Comparator | Alcohol | Other / unclassified | 100 % | Intravenous |
| Comparator | Nicotine | Unknown | 0.00714286 mg/kg | Intravenous |
| Comparator | Nicotine | Unknown | 0.0142857 mg/kg | Intravenous |
Indications
No indication recorded.