drugset / Trial / NCT01819441

Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients

NCT01819441

Phase 4 Unknown 1200 enrolled Yining Huang
RandomizedParallel-groupOpen-labelTreatment

Summary

A. the controlling of the blood pressure, especially the variation of blood pressure, can slow down the development of the small vessel disease. B intensive BP control is more effective than normal control of blood pressure in slowing down the small vessel disease. C drugs of Calcium Channel Blocker(CCB) and Angiotensin-Converting Enzyme Inhibitor(ACEI) have no significant difference in lowing the blood pressure and variability of blood pressure

Timeline

Start
2012-05
Primary completion
2016-12
Completion
2016-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Azelnidipine Small molecule 8 mg
Subject Azelnidipine Small molecule 16 mg
Subject Perindopril Small molecule 4 mg
Subject Perindopril Small molecule 8 mg
Background Hydrochlorothiazide Unknown 12.5 mg
Background Hydrochlorothiazide Unknown 25 mg