drugset / Trial / NCT01819441
Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients
RandomizedParallel-groupOpen-labelTreatment
Summary
A. the controlling of the blood pressure, especially the variation of blood pressure, can slow down the development of the small vessel disease. B intensive BP control is more effective than normal control of blood pressure in slowing down the small vessel disease. C drugs of Calcium Channel Blocker(CCB) and Angiotensin-Converting Enzyme Inhibitor(ACEI) have no significant difference in lowing the blood pressure and variability of blood pressure
Timeline
- Start
- 2012-05
- Primary completion
- 2016-12
- Completion
- 2016-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Azelnidipine | Small molecule | 8 mg | — |
| Subject | Azelnidipine | Small molecule | 16 mg | — |
| Subject | Perindopril | Small molecule | 4 mg | — |
| Subject | Perindopril | Small molecule | 8 mg | — |
| Background | Hydrochlorothiazide | Unknown | 12.5 mg | — |
| Background | Hydrochlorothiazide | Unknown | 25 mg | — |