Atorvastatin Before Prostatectomy and Prostate Cancer

Phase 2 Completed 160 enrolled Tampere University Hospital Fimlab laboratories · collab Finnish Cultural Foundation · collab Tampere University · collab University of Eastern Finland · collab

RandomizedParallel-groupTriple-blindPrevention

Summary

This single-center, randomized, double-blind trial assesses the impact of short-term atorvastatin administration on proliferation activity, apoptotic rate and histological inflammation in prostate tissue.

Timeline

Start: 2012-08
Primary completion: 2017-05
Completion: 2017-05

Publications

Raittinen PVH, Syvala H, Tammela TLJ, Hakkinen MR, Ilmonen P, Auriola S, Murtola TJ. Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial. EBioMedicine. 2021 Jun;68:103432. doi: 10.1016/j.ebiom.2021.103432. Epub 2021 Jun 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	80 mg	Oral

Atorvastatin Before Prostatectomy and Prostate Cancer

Summary

Timeline

Publications

Drugs

Indications