Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression

Summary

The purpose of this study is to improve behavior control displayed by persons with traumatic brain injury by assessing effectiveness of treatments for post-TBI irritability and aggression.

Timeline

Start

2013-05-15

Primary completion

2025-09-26

Completion

2025-09-26

Publications

• Hammond FM, Malec JF, Runkel R, Waltzman D, Tang Q, Ren J. Buspirone for Irritability and Aggression in Chronic Traumatic Brain Injury: A 91-Day Flexible-Dose, Parallel Group, Randomized, Placebo-Controlled Study. J Head Trauma Rehabil. 2026 May 8. doi: 10.1097/HTR.0000000000001174. Online ahead of print.

Drugs

Indications