drugset / Trial / NCT01825408

Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis

NCT01825408

Phase 4 Completed 40 enrolled University of North Carolina, Chapel Hill
RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine the best duration(3 versus 6 weeks) of antibiotics as part of maximal medical therapy for treating chronic sinusitis and thus preventing patients from having to have sinus surgery. The hypothesis is that in the context of maximal medical therapy 3 weeks of antibiotics is not worse than 6 weeks of antibiotics at successfully treating chronic sinusitis.

Timeline

Start
2013-02
Primary completion
2014-06
Completion
2014-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Amoxicillin Other / unclassified 875 mg
Comparator Azithromycin Small molecule 250 mg
Comparator Doxycycline Small molecule 100 mg

Indications