Pharmacokinetic Drug Interaction Study Between Gemigliptin and Irbesartan After Oral Administration in Healthy Male Subjects

Phase 1 Completed 30 enrolled LG Life Sciences

RandomizedCrossoverOpen-label

Summary

The objective of the study is to investigate the drug interaction between Gemigliptin and Irbesartan by comparing pharmacokinetics of Gemigliptin and Irbesartan administered concomitantly and each alone in healthy male subjects.

Timeline

Start: 2013-06
Primary completion: 2013-09
Completion: 2014-03

Publications

Choi HY, Lim HS, Kim YH, Jeon HS, Kim MJ, Lee SH, Jung JH, Lee YK, Kim HJ, Bae KS. Evaluation of the pharmacokinetics of the DPP-4 inhibitor gemigliptin when coadministered with rosuvastatin or irbesartan to healthy subjects. Curr Med Res Opin. 2015 Feb;31(2):229-41. doi: 10.1185/03007995.2014.980886. Epub 2014 Nov 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gemigliptin	Small molecule	50 mg	Oral
Subject	Irbesartan	Small molecule	300 mg	Oral

Indications

No indication recorded.