drugset / Trial / NCT01826838

Study of Dasatinib, Androgen Deprivation Therapy and Radiation

NCT01826838

Phase 1 Withdrawn Brown University
NaSingle-groupOpen-labelTreatment

Summary

Radiation and androgen deprivation is a common modality for patients with localized prostate cancer. Unfortunately for patients with intermediate to high risk prostate cancer incomplete tumor eradication and subsequent relapse occurs in 50-75% of patients. The Src pathway appears to be integral to the pathobiology of prostate cancer and may be fundamental to radioresistance.

Timeline

Start
2013-01
Primary completion
2013-04
Completion
2013-04

Drugs

EvaluationDrugModalityDoseRoute
Subject dasatinib anhydrous Small molecule 50 mg
Subject dasatinib anhydrous Small molecule 70 mg
Subject dasatinib anhydrous Small molecule 100 mg

Indications