drugset / Trial / NCT01835184

Cabozantinib-S-Malate and Vemurafenib in Treating Patients With Solid Tumors or Melanoma That is Metastatic or That Cannot Be Removed By Surgery

NCT01835184

Phase 1 Terminated 5 enrolled National Cancer Institute (NCI)
NaSingle-groupOpen-labelTreatment

Summary

This phase I trial studies the side effects and best dose of cabozantinib-s-malate when given together with vemurafenib in treating patients with solid tumors or melanoma that is metastatic or that cannot be removed by surgery. Cabozantinib-s-malate and vemurafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Timeline

Start
2013-05
Primary completion
2014-09
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject Cabozantinib Small molecule Oral
Subject Vemurafenib Small molecule Oral

Indications