Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency

Summary

The purpose of this study is to evaluate the efficacy and safety of the fixed-dose combination of coumarin and troxerutin versus placebo in the symptomatic treatment of chronic venous insufficiency.

Timeline

Start

2013-05

Primary completion

2015-09

Completion

2015-09

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Coumarin + Troxerutin vs Placebo; p = 0.531; Mean Difference (Final Values) -4.65 (95% CI -19.81 to 10.51); Regression, Linear NCT01848210 ↗

Publications

• Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D, Uriona Tuma SM, Stein AT, Moreno Carriles RMM, Vargas E, Bonfill Cosp X. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4.

Drugs

Indications