CD34+ Stem Cell Infusion to Augment Graft Function

Summary

The purpose of this study is to determine if infusing additional special donor cells will help to improve graft or immune function in previously transplanted children with immune deficiencies and bone marrow failures.

Timeline

Start

2010-10

Primary completion

2018-08-15

Completion

2018-08-15

Outcome

Outcome not reported

Stopped: “CliniMACS CD34 Reagent System was FDA approved for clinical use; therefore, patients were treated clinically.”

Publications

• Results Chandra S, Bleesing JJ, Jordan MB, Grimley MS, Khandelwal P, Davies SM, Edwards S, Leemhuis T, Marsh RA. Post-Transplant CD34+ Selected Stem Cell "Boost" for Mixed Chimerism after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation in Children and Young Adults with Primary Immune Deficiencies. Biol Blood Marrow Transplant. 2018 Jul;24(7):1527-1529. doi: 10.1016/j.bbmt.2018.03.013. Epub 2018 Mar 16.

Drugs

Indications