Optimizing the Use of Entonox® During Screening Colonoscopy

Phase 4 Completed 100 enrolled Sheffield Teaching Hospitals NHS Foundation Trust

RandomizedParallel-groupOpen-labelTreatment

Summary

This study will randomise patients undergoing screening colonoscopy to receive Entonox either continuously or as required. Both these methods are used in the published studies of Entonox and in clinical practice. Null hypothesis There will be no difference in pain levels between these two methods of Entonox administration

Timeline

Start: 2013-01
Primary completion: 2014-04
Completion: 2014-04

Publications

Ball AJ, Din S, Donnelly M, Riley SA. A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy. Eur J Gastroenterol Hepatol. 2015 Mar;27(3):271-8. doi: 10.1097/MEG.0000000000000281.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Entonox	Unknown	—	Inhaled

Indications

No indication recorded.