Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients

Summary

* Assessment of pharmacokinetic parameters of once daily subcutaneously administered methylnaltrexone in 10 evaluable neurointensive care patients. * Quantification of methylnaltrexone passage through the blood-brain-barrier in critically ill patients with severe cerebral affections. * Observation of laxation response after methylnaltrexone application and relation to plasma concentrations of methylnaltrexone. * Assessing the safety of once daily administered methylnaltrexone in neurointensive care patients. * Trial with medicinal product

Timeline

Start

2014-02

Primary completion

2016-06

Completion

2016-06

Drugs

Indications