drugset / Trial / NCT01901848

CPT and Smoking Cessation

NCT01901848

Phase 2/3 Completed 69 enrolled VA Office of Research and Development
RandomizedParallel-groupSingle-blindTreatment

Summary

Posttraumatic stress disorder (PTSD) and cigarette smoking are both associated with significant impairment in Veterans and cost to the Veterans' Affairs (VA) system. Though research suggests smoking is linked with PTSD symptoms, existing smoking cessation treatments targeting PTSD smokers do not include PTSD treatment. The purpose of this study is to examine a treatment that combines evidence based treatment for PTSD (cognitive processing therapy, or CPT) with smoking cessation treatment for PTSD and a mobile text messaging program. The study objectives are to evaluate feasibility of the treatment and to examine effectiveness of CPT and smoking cessation treatment combined compared to smoking cessation treatment without CPT. Fifty Veteran smokers with PTSD will participate in fourteen study sessions, ending with the final follow-up session six months after the scheduled quit date.

Timeline

Start
2013-12-11
Primary completion
2017-07-30
Completion
2017-07-30

Drugs

EvaluationDrugModalityDoseRoute
Background Bupropion Small molecule
Background Nicotine Unknown