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A Clinical Trial to Investigate the Influence of CES1 Polymorphism on Oseltamivir

NCT01902342 ↗

Phase 1 Completed 20 enrolled Seoul National University Hospital

Non-randomizedParallel-groupOpen-labelBasic science

Summary

Investigate genetic variability of CES1 gene on pharmacokinetics of oseltamivir in healthy Korean volunteers.

Timeline

Start: 2013-07
Primary completion: 2013-12
Completion: 2013-12

Publications

Oh J, Lee S, Lee H, Cho JY, Yoon SH, Jang IJ, Yu KS, Lim KS. The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. PLoS One. 2017 Apr 24;12(4):e0176320. doi: 10.1371/journal.pone.0176320. eCollection 2017.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oseltamivir	Small molecule	75 mg	Oral

Indications

No indication recorded.