A Study To Evaluate The PDE10 Enzyme Occupancy Following A Single Dose Of PF-02545920 In Healthy Male Volunteers

NCT01918202 ↗

Phase 1 Completed 9 enrolled Pfizer

Non-randomizedSingle-groupOpen-labelBasic science

Summary

This Phase 1 study will evaluate PDE10 enzyme occupancy using Positron Emission Tomography after a single dose of PF-02545920 in Healthy male volunteers.

Timeline

Start: 2014-03
Primary completion: 2014-09
Completion: 2014-09

Publications

Delnomdedieu M, Forsberg A, Ogden A, Fazio P, Yu CR, Stenkrona P, Duvvuri S, David W, Al-Tawil N, Vitolo OV, Amini N, Nag S, Halldin C, Varrone A. In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects. Neuropharmacology. 2017 May 1;117:171-181. doi: 10.1016/j.neuropharm.2017.01.016. Epub 2017 Jan 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	MARDEPODECT	Small molecule	1 mg	Oral
Subject	MARDEPODECT	Small molecule	2 mg	Oral
Subject	MARDEPODECT	Small molecule	5 mg	Oral
Subject	MARDEPODECT	Small molecule	10 mg	Oral
Subject	MARDEPODECT	Small molecule	20 mg	Oral
Subject	MARDEPODECT	Small molecule	30 mg	Oral

Indications

No indication recorded.